Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity


The CD4+ and CD8+ T cell dichotomy is essential for effective cellular immunity. How individual T cell identity is established remains poorly understood. Here we show that the high-mobility group (HMG) transcription factors Tcf1 and Lef1 are essential for repressing CD4+ lineage–associated genes including Cd4, Foxp3 and Rorc in CD8+ T cells. Tcf1- and Lef1… (More)
DOI: 10.1038/ni.3456