Tc-99m HMPAO SPECT in the Differential Diagnosis of the Dementias With Histopathologic Confirmation

@article{Bonte2006Tc99mHS,
  title={Tc-99m HMPAO SPECT in the Differential Diagnosis of the Dementias With Histopathologic Confirmation},
  author={Frederick J. Bonte and Thomas S. Harris and Linda S. Hynan and Eileen H. Bigio and Charles L. White},
  journal={Clinical Nuclear Medicine},
  year={2006},
  volume={31},
  pages={376-378}
}
Purpose: The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias, with particular reference to Alzheimer disease. Materials and Methods: Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Diagnosis was made by a physician blinded to the clinical diagnosis. Results in 49 subjects were ultimately compared with neuropathologic study of the brain at autopsy. Results: Sensitivity = 86.7% (68.4–95.6… 
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