Tc-99m HMPAO SPECT in the Differential Diagnosis of the Dementias With Histopathologic Confirmation

  title={Tc-99m HMPAO SPECT in the Differential Diagnosis of the Dementias With Histopathologic Confirmation},
  author={Frederick J. Bonte and Thomas S. Harris and Linda S. Hynan and Eileen H. Bigio and Charles L. White},
  journal={Clinical Nuclear Medicine},
Purpose: The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias, with particular reference to Alzheimer disease. Materials and Methods: Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Diagnosis was made by a physician blinded to the clinical diagnosis. Results in 49 subjects were ultimately compared with neuropathologic study of the brain at autopsy. Results: Sensitivity = 86.7% (68.4–95.6… 
TC-99m HMPAO Brain Blood Flow Imaging in the Dementias with Histopathologic Correlation in 73 Patients
Tc-99m HMPAO SPECT is widely available and relatively inexpensive and may be of value in patients with dementias and problematic diagnoses and a degree of differential diagnosis between Alzheimer's and Frontotemporal diseases may be effected.
Tc-99m ethylcysteinate dimer SPECT in the differential diagnosis of dementias.
Tc-99m ECD brain perfusion SPECT is useful in the differential diagnosis of dementia with particular reference to AD as well as FTD, as evaluated in 136 patients referred from the dementia clinic.
Accuracy of single-photon emission computed tomography in differentiating frontotemporal dementia from Alzheimer’s disease
Technetium-99-labelled hexamethyl propylene amine oxime SPECT CBF patterns provide valuable information in the diagnosis of FTD and AD, and can be better used as an adjunct to clinical diagnosis if pathology is to be correctly predicted in life.
Role of imaging techniques in the diagnosis of dementia.
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  • Medicine
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  • 2007
Regionally distinct patterns of hypoperfusion on single-photon emission computed tomography (SPECT) or hypometabolism on positron emission tomographic (PET) can help differentiate FTD, AD and VaD, and dopaminergic loss in the basal ganglia can differentiate DLB from AD.
The diagnosis and evaluation of dementia and mild cognitive impairment with emphasis on SPECT perfusion neuroimaging
In the face of expensive new markers and limited availability of cyclotrons, single photon emission computer tomography (SPECT) provides relatively high sensitivity and specificity at a comparatively low overall cost.
Systematic literature review and meta-analysis of diagnostic test accuracy in Alzheimer's disease and other dementia using autopsy as standard of truth.
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Specific Ways Brain SPECT Imaging Enhances Clinical Psychiatric Practice
SPECT has the potential to add clinically meaningful information to enhance patient care beyond current assessment tools in complex or treatment resistant cases.
The Legacy of the TTASAAN Report—Premature Conclusions and Forgotten Promises: A Review of Policy and Practice Part I
At the 25-year anniversary of the publication of the TTASAAN report, the utility of perfusion SPECT brain imaging is re-examine and technical aspects of SPECT neuroimaging are elaborate and discuss scan interpretation for the clinician.
Application of Artificial Neural Networks to Identify Alzheimer’s Disease Using Cerebral Perfusion SPECT Data
In conclusion, artificial neural networks and conventional statistics methods (discriminant analysis) are a useful tool in Alzheimer disease diagnosis.


Brain blood flow in the dementias: SPECT with histopathologic correlation in 54 patients.
PURPOSE To evaluate single photon emission computed tomographic (SPECT) imaging of regional cerebral blood flow in the diagnosis of Alzheimer disease (AD) and the differential diagnosis of the
Accurate prediction of histologically confirmed Alzheimer's disease and the differential diagnosis of dementia: the use of NINCDS-ADRDA and DSM-III-R criteria, SPECT, X-ray CT, and APO E4 medial temporal lobe dementias. The Oxford Project to Investigate Memory and Aging.
The diagnostic accuracy afforded by this method of CT and SPECT used alone is better than that of any established clinical criteria and reveals that the combination of MTL atrophy and parietotemporal hypoperfusion is common in AD, much less common in other dementias, and rare in normal controls.
FDG PET imaging in patients with pathologically verified dementia.
This study confirms that bilateral temporo-parietal hypometabolism is indeed the classic metabolic abnormality associated with AD and the sensitivity, specificity, and diagnostic accuracy of FDG PET are acceptable as tests to be used in the evaluation of dementia and particularly to confirm the clinical suspicion of AD.
Alzheimer's disease versus dementia with Lewy bodies: Cerebral metabolic distinction with autopsy confirmation
Analysis of clinically‐diagnosed probable AD patients showed a significantly higher frequency of primary visual metabolic reduction among patients who fulfilled later clinical criteria for DLB, and occipital hypometabolism is a potential antemortem marker to distinguish DLB versus AD.
Differential diagnosis between Alzheimer's and frontotemporal disease by the posterior cingulate sign.
When present, the posterior cingulate sign indicates the presence of Alzheimer's disease; it is apparently absent in frontotemporal disease, thus serving as a differential diagnostic sign.
Statistical parametric maps in functional imaging: A general linear approach
Statistical parametric maps are spatially extended statistical processes that are used to test hypotheses about regionally specific effects in neuroimaging data. The most established sorts of
Posterior cingulate cortex in Alzheimer's disease
Posterior cingulate sign in differential diagnosis between Alzheimer’s disease and frontotemporal diseases
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  • 2004
Brain blood flow in the dementias: SPECT with histopathologic correlation.
When compared with histopathologic diagnosis, clinical diagnosis was correct in 15 of 18 patients; visual scanning diagnosis, in 13 of 18; and Xe-133-SPECT diagnosis based on quantitative ratios in regions of interest, in 14 of 15 (13 of 13 with Alzheimer disease).