Tbx6, Thylacine1, and E47 synergistically activate bowline expression in Xenopus somitogenesis.

@article{Hitachi2008Tbx6TA,
  title={Tbx6, Thylacine1, and E47 synergistically activate bowline expression in Xenopus somitogenesis.},
  author={Keisuke Hitachi and Akiko Kondow and Hiroki Danno and Masafumi Inui and Hideho Uchiyama and Makoto Asashima},
  journal={Developmental biology},
  year={2008},
  volume={313 2},
  pages={816-28}
}
T-box factor, Tbx6, is a prerequisite for somite segmentation in vertebrates. We recently identified a negative regulator of Tbx6, Bowline, which represses the expression of genes involved in somite segmentation by suppressing the transcriptional activity of Tbx6. According to this function, bowline gene expression is restricted to the most anterior presomitic mesoderm where the somite segmentation program terminates, although it remains unclear how bowline expression is activated. To address… CONTINUE READING

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