Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis

@inproceedings{Takeuchi2003Tbx5ST,
  title={Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis},
  author={Jun K. Takeuchi and Makoto Ohgi and Kazuko Koshiba-Takeuchi and Hidetaka Shiratori and Ichiro Sakaki and Keiko Ogura and Yukio Saijoh and Toshihiko Ogura},
  year={2003}
}
Extensive misexpression studies were carried out to explore the roles played by Tbx5, the expression of which is excluded from the right ventricle (RV) during cardiogenesis. When Tbx5 was misexpressed ubiquitously, ventricular septum was not formed, resulting in a single ventricle. In such heart, left ventricle (LV)-specific ANF gene was induced. In search of the putative RV factor(s), we have found that chick Tbx20 is expressed in the RV, showing a complementary fashion to Tbx5. In the Tbx5… CONTINUE READING

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