Tbx5 is required for forelimb bud formation and continued outgrowth.

@article{Rallis2003Tbx5IR,
  title={Tbx5 is required for forelimb bud formation and continued outgrowth.},
  author={Charalampos Rallis and Benoit G Bruneau and Jo del Buono and Christine E Seidman and Jonathan G Seidman and Sahar Nissim and Clifford J Tabin and Malcolm P. O. Logan},
  journal={Development},
  year={2003},
  volume={130 12},
  pages={2741-51}
}
Tbx5 is a T-box transcription factor expressed exclusively in the developing forelimb but not in the developing hindlimb of vertebrates. Tbx5 is first detected in the prospective forelimb mesenchyme prior to overt limb bud outgrowth and its expression is maintained throughout later limb development stages. Direct evidence for a role of Tbx5 in forelimb development was provided by the discovery that mutations in human TBX5 cause Holt-Oram Syndrome (HOS), a dominant disorder characterised… CONTINUE READING
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