Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma

@inproceedings{Burgucu2012Tbx3RP,
  title={Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma},
  author={Durmuş Burgucu and Kenan Guney and Duygu Sahinturk and Irem Hicran Ozbudak and Deniz Ozel and Gulay Ozbilim and Ugur Yavuzer},
  booktitle={BMC Cancer},
  year={2012}
}
Despite advances in diagnostic and treatment strategies, head and neck squamous cell cancer (HNSCC) constitutes one of the worst cancer types in terms of prognosis. PTEN is one of the tumour suppressors whose expression and/or activity have been found to be reduced in HNSCC, with rather low rates of mutations within the PTEN gene (6-8%). We reasoned that low expression levels of PTEN might be due to a transcriptional repression governed by an oncogene. Tbx2 and Tbx3, both of which are… CONTINUE READING