Tbx3 is required for outflow tract development.

  title={Tbx3 is required for outflow tract development.},
  author={Karim Mesbah and Zachary Harrelson and Magali Th{\'e}veniau-Ruissy and Virginia E Papaioannou and Robert G. Kelly},
  journal={Circulation research},
  volume={103 7},
Conotruncal and ventricular septal congenital heart anomalies result from defects in formation and division of the embryonic outflow tract. Cardiac remodeling during outflow tract and ventricular septation converts the tubular embryonic heart into a parallel circulatory system with an independent left ventricular outlet and right ventricular inlet. Tbx3 encodes a T-box-containing transcription factor expressed in the developing conduction system of the heart. Mutations in TBX3 cause ulnar… CONTINUE READING


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