Tbx20 regulation of endocardial cushion cell proliferation and extracellular matrix gene expression.

@article{Shelton2007Tbx20RO,
  title={Tbx20 regulation of endocardial cushion cell proliferation and extracellular matrix gene expression.},
  author={Elaine L. Shelton and Katherine E. Yutzey},
  journal={Developmental biology},
  year={2007},
  volume={302 2},
  pages={376-88}
}
While recent work has implicated Tbx20 in myocardial maturation and proliferation, the role of Tbx20 in heart valve development remains relatively unknown. Tbx20 expression was manipulated in primary avian endocardial cells in order to elucidate its function in developing endocardial cushions. Tbx20 gain of function was achieved with a Tbx20-adenovirus, and endogenous Tbx20 expression was inhibited with Tbx20-specific siRNA in cultured endocardial cushion cells. With Tbx20 gain of function, the… CONTINUE READING

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