Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney.

@article{Xu2014Tbx18IE,
  title={Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney.},
  author={Jinshu Xu and Xuguang Nie and Xiaoqiang Cai and Chen-leng Cai and Pin-Xian Xu},
  journal={Developmental biology},
  year={2014},
  volume={391 1},
  pages={17-31}
}
Tbx18 has been shown to be essential for ureteral development. However, it remains unclear whether it plays a direct role in kidney development. Here we addressed this by focusing on examining the pattern and contribution of Tbx18+ cells in the kidney and its role in kidney vascular development. Expression studies and genetic lineage tracing revealed that Tbx18 is expressed in renal capsule, vascular smooth muscle cells and pericytes and glomerular mesangial cells in the kidney and that Tbx18… CONTINUE READING