Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field.

@article{Nowotschin2006Tbx1AA,
  title={Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field.},
  author={Sonja Nowotschin and Jun Liao and Philip J. Gage and Jonathan A. Epstein and Marina Campione and Bernice E Morrow},
  journal={Development},
  year={2006},
  volume={133 8},
  pages={1565-73}
}
Individuals with 22q11 deletion syndrome (22q11DS; DiGeorge/velo-cardio-facial syndrome) have multiple congenital malformations, including cardiovascular defects. Most individuals with this syndrome possess 1.5-3.0 Mb hemizygous 22q11.2 deletions. The T-box transcription factor TBX1, lies within the nested 1.5 Mb interval and is a strong candidate for its etiology. Inactivation of Tbx1 in the mouse results in neonatal lethality owing to the presence of a single cardiac outflow tract. One… CONTINUE READING
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