TbtABM, a multidrug efflux pump associated with tributyltin resistance in Pseudomonas stutzeri.

@article{Jude2004TbtABMAM,
  title={TbtABM, a multidrug efflux pump associated with tributyltin resistance in Pseudomonas stutzeri.},
  author={Florence Jude and Corinne Arpin and C{\'e}line Brachet-Castang and Mich{\`e}le Capdepuy and Pierre Caumette and Claudine Quentin},
  journal={FEMS microbiology letters},
  year={2004},
  volume={232 1},
  pages={7-14}
}
Tributyltin (TBT) is a toxic agent used in marine antifouling paints. Among the bacterial flora of a polluted harbor, TBT-resistant strains of Pseudomonas stutzeri have been isolated. In the strain 5MP1 (TBT minimum inhibitory concentration (MIC) > or =1000 mg l(-1)), TBT resistance was found to be associated with the presence of the operon tbtABM, homologous to the resistance-nodulation-cell division (RND) efflux pump family, as demonstrated by cloning in Escherichia coli. TbtABM exhibited the… CONTINUE READING