TbISWI regulates multiple polymerase I (Pol I)-transcribed loci and is present at Pol II transcription boundaries in Trypanosoma brucei.

@article{Stanne2011TbISWIRM,
  title={TbISWI regulates multiple polymerase I (Pol I)-transcribed loci and is present at Pol II transcription boundaries in Trypanosoma brucei.},
  author={Tara M. Stanne and Manish Kushwaha and Matthew P. Wand and Jesse E. Taylor and Gloria Rudenko},
  journal={Eukaryotic cell},
  year={2011},
  volume={10 7},
  pages={964-76}
}
The unicellular eukaryote Trypanosoma brucei is unusual in having very little transcriptional control. The bulk of the T. brucei genome is constitutively transcribed by RNA polymerase II (Pol II) as extensive polycistronic transcription units. Exceptions to this rule include several RNA Pol I transcription units such as the VSG expression sites (ESs), which are mono-allelically expressed. TbISWI, a member of the SWI2/SNF2 related chromatin remodeling ATPases, plays a role in repression of Pol I… CONTINUE READING

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