Tazarotene-Induced Gene 1 Enhanced Cervical Cell Autophagy through Transmembrane Protein 192

@inproceedings{Shyu2016TazaroteneInducedG1,
  title={Tazarotene-Induced Gene 1 Enhanced Cervical Cell Autophagy through Transmembrane Protein 192},
  author={R. J. Shyu and Chun-Hua Wang and C T Wu and Mao-Liang Chen and Ming-Cheng Lee and L F Wang and S. Jiang and Fu-Ming Tsai},
  booktitle={Molecules and cells},
  year={2016}
}
Tazarotene-induced gene 1 (TIG1) is a retinoic acid-inducible protein that is considered a putative tumor suppressor. The expression of TIG1 is decreased in malignant prostate carcinoma or poorly differentiated colorectal adenocarcinoma, but TIG1 is present in benign or well-differentiated tumors. Ectopic TIG1 expression led to suppression of growth in cancer cells. However, the function of TIG1 in cell differentiation is still unknown. Using a yeast two-hybrid system, we found that… CONTINUE READING