Tay-Sachs Disease: Generalized Absence of a Beta-D-N-Acetylhexosaminidase Component

  title={Tay-Sachs Disease: Generalized Absence of a Beta-D-N-Acetylhexosaminidase Component},
  author={S. Okada and J. O'brien},
  pages={698 - 700}
  • S. Okada, J. O'brien
  • Published 1969
  • Biology, Medicine
  • Science
  • Two hexosaminidase components, separable by starch-gel electrophoresis and possessing both β-D-N-acetylglucosaminidase and β-D-N-acetylgalactosaminidase activity, are present in human tissues. One of these, hexosaminidase component A, is absent in brain, liver, kidney, skin, cultured skin fibroblasts, blood plasma, and leukocytes from nine patients with Tay-Sachs disease. Hexosaminidase assay may facilitate the early diagnosis of individuals homozygous for Tay-Sachs disease. 
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