Taxonomy proposal for Old World monkey adenoviruses: characterisation of several non-human, non-ape primate adenovirus lineages

  title={Taxonomy proposal for Old World monkey adenoviruses: characterisation of several non-human, non-ape primate adenovirus lineages},
  author={Laura Pant{\'o} and Iva I Podgorski and M{\'a}t{\'e} J{\'a}noska and Orsolya M{\'a}rk{\'o} and Bal{\'a}zs Harrach},
  journal={Archives of Virology},
A species classification regarding Old World monkey adenoviruses is proposed. We determined the nucleotide sequences of PCR-amplified fragments from the genes of the IVa2, DNA-dependent DNA polymerase, penton base, and hexon proteins from every simian adenovirus (SAdV) serotype that originated from Old World monkeys for which the full genome sequence had not yet been published. We confirmed that the majority of Old Word monkey SAdVs belong to two previously established species. Interestingly… 

Genome analysis of four Old World monkey adenoviruses supports the proposed species classification of primate adenoviruses and reveals signs of possible homologous recombination.

Phylogenetic calculations implied that recombination events might have happened between different AdV species, andylogeny inference, based on the viral DNA-dependent DNA polymerase and the penton base protein, supported the species classification proposed earlier.

Adenovirus Infections in African Humans and Wild Non-Human Primates: Great Diversity and Cross-Species Transmission

Investigating the occurrence and diversity of AdVs in fecal samples of apes and monkeys from different African countries and stool of humans living near gorillas in the Republic of Congo confirmed the gorilla-to-human transmission of adenovirus.

Adenoviruses of the most ancient primate lineages support the theory on virus-host co-evolution.

Phylogenetic analysis indicated that the tentative novel AdVs cluster into two separate groups, which form the most basal branches among the primate AdVs, and therefore support the theory on the co-evolution of primate adenoviruses with their hosts.

Epidemiological and molecular characterization of a novel adenovirus of squirrel monkeys after fatal infection during immunosuppression

RP testing and partial sequencing of 95 archived faecal samples from other squirrel monkeys housed at the KCCMR revealed the presence of three distinct, and apparently endemic species of adenoviruses, suggesting that squirrel monkeys may be the natural host of the TMAdV.

Isolation and characterization of adenoviruses infecting endangered golden snub-nosed monkeys (Rhinopithecus roxellana)

It is reported for the first time the isolation and full-length genomic characterization of an adenovirus from the subfamily Colobinae, and it is revealed that this virus represents a novel species in the genus Mastadenovirus.

Genomics-based re-examination of the taxonomy and phylogeny of human and simian Mastadenoviruses: an evolving whole genomes approach, revealing putative zoonosis, anthroponosis, and amphizoonosis.

An evaluation of 174 whole genome sequences from HAdVs and SAdVs archived in GenBank finds that rather than separate HAdV and S adenovirus phylogenetic lineages, a single, intertwined tree is observed with all HAd ads and S AdVs forming mixed clades.

Complete genome analysis confirms that the pygmy marmoset adenovirus is a variant of the skunk adenovirus 1 - Short communication.

A novel species Skunk mastadenovirus A (SkAdV-A) has been established, and the AdVs, originating from the African pygmy hedgehogs, have been found to belong to virus species SkAdv-A.

Non-Human Primate-Derived Adenoviruses for Future Use as Oncolytic Agents?

  • S. BotsR. Hoeben
  • Medicine, Biology
    International journal of molecular sciences
  • 2020
The similarities and differences between human- and NHP-derived adenoviruses in view of their use as oncolytic agents, including their genome organization, receptor use, replication and cell lysis, modulation of the host’s immune responses, as well as their pathogenicity in humans are discussed.



Identification of New Provisional Simian Adenovirus Species from Captive Monkeys, China

Ten novel simian adenovirus strains were detected by using PCR and hexon gene–specific primers and characterized by sequencing the entire open-reading frames of the hexon genes, which revealed 9 previously reported hypervariable regions (HVRs): HVR1–HVR9.

Analysis of the first complete genome sequence of an Old World monkey adenovirus reveals a lineage distinct from the six human adenovirus species.

Determination of the complete DNA sequence of SAdV-3 permitted the first full genomic comparison of a monkey adenovirus withAdenoviruses of humans (HAdVs) and chimpanzees, which are recognized formally as constituting six of the species within the genus Mastadenovirus.

Complete genome sequence of simian adenovirus 1: an Old World monkey adenovirus with two fiber genes.

The genome sequence of SAdV-1 was determined and analysed and, based on phylogenetic distances and other taxonomic criteria, SAdv-1 is proposed to represent a novel adenovirus species.

Isolation of a novel monkey adenovirus reveals a new phylogenetic clade in the evolutionary history of simian adenoviruses

The study of the evolutionary relationships of this new monkey AdV based on the combined sequences of the four genes supported a close relationship to SAdV-3 and SAdv-6, lineages isolated from Rhesus monkeys.

Cross-Species Transmission of a Novel Adenovirus Associated with a Fulminant Pneumonia Outbreak in a New World Monkey Colony

The discovery of TMAdV, a novel adenovirus with the capacity to infect both monkeys and humans, suggests thatAdenoviruses should be monitored closely as potential causes of cross-species outbreaks.

Novel Adenoviruses in Wild Primates: a High Level of Genetic Diversity and Evidence of Zoonotic Transmissions

This study identified AdVs in NHPs living in their natural habitats, and through the combination of phylogenetic analyses and information on the habitats and epidemiological settings, it detected possible horizontal transmission events between NHPs and humans.

The genome sequence of a novel simian adenovirus in a chimpanzee reveals a close relationship to human adenoviruses

Phylogenetic analysis revealed SAdV-ch1 clustering in a clade that was separate from all of the other simian AdVs but genetically close to a human AdV strain, HAdv-18 (GenBank no. GU191019), sharing 92.5 % sequence identity with it.

A Novel Adenovirus Species Associated with an Acute Respiratory Outbreak in a Baboon Colony and Evidence of Coincident Human Infection

The results implicate a novel adenovirus species (SAdV-C) in an acute respiratory outbreak in a baboon colony and underscore the potential for cross-species transmission of AdVs between humans and nonhuman primates.

Isolation and Characterization of Adenoviruses Persistently Shed from the Gastrointestinal Tract of Non-Human Primates

The high degree of asymptomatic shedding of live adenovirus in non-human primates and evidence for zoonotic transmissions warrants caution for primate handling and housing, and the presence of persistent and/or latent adnovirus infections in the gut should be considered in the design and interpretation of human and non- human primate studies with adanovirus vectors.