Taxonomy proposal for Old World monkey adenoviruses: characterisation of several non-human, non-ape primate adenovirus lineages

  title={Taxonomy proposal for Old World monkey adenoviruses: characterisation of several non-human, non-ape primate adenovirus lineages},
  author={Laura Pant{\'o} and Iva I Podgorski and M{\'a}t{\'e} J{\'a}noska and Orsolya M{\'a}rk{\'o} and Bal{\'a}zs Harrach},
  journal={Archives of Virology},
  pages={3165 - 3177}
A species classification regarding Old World monkey adenoviruses is proposed. We determined the nucleotide sequences of PCR-amplified fragments from the genes of the IVa2, DNA-dependent DNA polymerase, penton base, and hexon proteins from every simian adenovirus (SAdV) serotype that originated from Old World monkeys for which the full genome sequence had not yet been published. We confirmed that the majority of Old Word monkey SAdVs belong to two previously established species. Interestingly… 

Genome analysis of four Old World monkey adenoviruses supports the proposed species classification of primate adenoviruses and reveals signs of possible homologous recombination.

Phylogenetic calculations implied that recombination events might have happened between different AdV species, andylogeny inference, based on the viral DNA-dependent DNA polymerase and the penton base protein, supported the species classification proposed earlier.

Genome Analyses of Ten New Ape Adenoviruses with Similarity to Human Mastadenovirus C

The sequence analyses of ten new AdVs that are related to the HAdV-C species and that were isolated from healthy western lowland gorillas, bonobos, chimpanzees, and orangutans kept in Dutch zoos suggest that these viruses form three well-separated clades and should each be given species-level ranks.

Adenovirus Infections in African Humans and Wild Non-Human Primates: Great Diversity and Cross-Species Transmission

Investigating the occurrence and diversity of AdVs in fecal samples of apes and monkeys from different African countries and stool of humans living near gorillas in the Republic of Congo confirmed the gorilla-to-human transmission of adenovirus.

Adenoviruses of the most ancient primate lineages support the theory on virus-host co-evolution.

Phylogenetic analysis indicated that the tentative novel AdVs cluster into two separate groups, which form the most basal branches among the primate AdVs, and therefore support the theory on the co-evolution of primate adenoviruses with their hosts.

Isolation and characterization of adenoviruses infecting endangered golden snub-nosed monkeys (Rhinopithecus roxellana)

It is reported for the first time the isolation and full-length genomic characterization of an adenovirus from the subfamily Colobinae, and it is revealed that this virus represents a novel species in the genus Mastadenovirus.

Genomics-based re-examination of the taxonomy and phylogeny of human and simian Mastadenoviruses: an evolving whole genomes approach, revealing putative zoonosis, anthroponosis, and amphizoonosis.

An evaluation of 174 whole genome sequences from HAdVs and SAdVs archived in GenBank finds that rather than separate HAdV and S adenovirus phylogenetic lineages, a single, intertwined tree is observed with all HAd ads and S AdVs forming mixed clades.

Complete genome analysis confirms that the pygmy marmoset adenovirus is a variant of the skunk adenovirus 1 - Short communication.

A novel species Skunk mastadenovirus A (SkAdV-A) has been established, and the AdVs, originating from the African pygmy hedgehogs, have been found to belong to virus species SkAdv-A.

Non-Human Primate-Derived Adenoviruses for Future Use as Oncolytic Agents?

  • S. BotsR. Hoeben
  • Medicine, Biology
    International journal of molecular sciences
  • 2020
The similarities and differences between human- and NHP-derived adenoviruses in view of their use as oncolytic agents, including their genome organization, receptor use, replication and cell lysis, modulation of the host’s immune responses, as well as their pathogenicity in humans are discussed.