Taxonomic assignment of uncultivated prokaryotic virus genomes is enabled by gene-sharing networks

@article{Jang2019TaxonomicAO,
  title={Taxonomic assignment of uncultivated prokaryotic virus genomes is enabled by gene-sharing networks},
  author={Ho Bin Jang and Benjamin Bolduc and Olivier Zablocki and Jens H. Kuhn and Simon Roux and Evelien M Adriaenssens and J. Rodney Brister and Andrew M. Kropinski and Mart Krupovic and R{\'e}gis Lavigne and Dann Turner and Matthew B. Sullivan},
  journal={Nature Biotechnology},
  year={2019},
  volume={37},
  pages={632-639}
}
Microbiomes from every environment contain a myriad of uncultivated archaeal and bacterial viruses, but studying these viruses is hampered by the lack of a universal, scalable taxonomic framework. We present vConTACT v.2.0, a network-based application utilizing whole genome gene-sharing profiles for virus taxonomy that integrates distance-based hierarchical clustering and confidence scores for all taxonomic predictions. We report near-identical (96%) replication of existing genus-level viral… CONTINUE READING
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