Taxon-specific differences in responsiveness to capsaicin and several analogues: Correlates between chemical structure and behavioral aversiveness

  title={Taxon-specific differences in responsiveness to capsaicin and several analogues: Correlates between chemical structure and behavioral aversiveness},
  author={J. Russell Mason and Noel J. Bean and Pankaj S. Shah and Larry Clark},
  journal={Journal of Chemical Ecology},
The present set of experiments was designed to explore avian insensitivity to capsaicin. Based upon a molecular model of avian chemosensory repellency, we hypothesized that structural modifications of the basic capsaicin molecule, which is itself not aversive to birds, might produce aversive analogues. To this end, European starlings (Sturnus vulgaris) and Norway rats (Rattus norvegicus) were given varied concentrations of synthetic capsaicin and four analogues (methyl capsaicin, veratryl amine… 
Tests and refinements of a general structure-activity model for avian repellents
The data suggest that there is ano-aminoacetophenone/methyl anthranilate trigeminal chemoreceptor in birds analogous to the mammalian capsaicin receptor, and that birds seem to lack the associated thiol/hydrogen-bonding site present in mammals which is needed to activate the benzene site.
From the SelectedWorks of Larry Clark 1993 AVOIDANCE OF BIRD REPELLENTS BY MICE
-It is believed that mammalian chemosensory irritants are not aversive to birds and vice versa. Nevertheless, few avian repellents have been tested against mammals. For that reason, we evaluated the
Avoidance of bird repellents by mice (Mus musculus)
O orthoaminoaceto-phenone was the most effective repellent, with intake reduced to levels statistically indistinguishable from zero.
Palatability and efficacy to possums and rats of pest control baits containing bird repellents
Two repellents combined, anthraquinone and DP as surface coatings on baits are acceptable to possums and possibly rats, at concentrations that deter some bird species.
Neural basis of trigeminal chemo- and thermonociception in brown treesnakes, Boiga irregularis (Squamata: Colubridae)
Brown treesnake trigeminal neurons responded to capsaicin, and these findings are of evolutionary interest as well as providing potential insights into managing this significant pest species.
Aerosolized essential oils and individual natural product compounds as brown treesnake repellents.
This study is the first to systematically investigate the irritant potential of natural products for snakes, and its data will be useful in the development of practical pest management tools for snakes.
Natural Resources Proceedings of the Vertebrate Pest Conference Title Nonlethal repellents : The development of cost-effective , practical solutions to agricultural and industrial problems
Repellents subsrances and devices canse pest species to avoid otherwise attraelive or palatable materials. For birds.. repellents can be visual, audilllry, pyrotechnic. tactile, chemosensory,
Heat and noxious chemical sensor, chicken TRPA1, as a target of bird repellents and identification of its structural determinants by multispecies functional comparison.
The results suggest that TRPA1 acted as a noxious chemical and heat receptor, and was coexpressed with TRPV1 in the ancestral terrestrial vertebrate, which is likely to have affected the functional evolution ofTRPA1 regarding thermal sensitivity and led to the diversification among diverse vertebrate species.
Calcium responses of chicken trigeminal ganglion neurons to methyl anthranilate and capsaicin
The findings that the calcium responses to MA and CAP have different ion dependencies and that there are separate populations sensitive to these compounds suggest different transduction mechanisms mediating chicken trigeminal responses toMA and CAP.
The Chemical Senses in Birds
The chemical senses generally fall into three categories: chemesthesis (irritation and pain), olfaction (smell), and gustation (taste). Traditionally, the emphasis in describing responsiveness to


Chemical repellency in birds: relationship between chemical structure and avoidance response.
The ability to generate a model predicting repellency allows for the efficient identification and development of ecologically sound, nonlethal, taxa-specific repellents to be used for the protection of wildlife in agricultural and industrial applications.
Prediction of avian repellency from chemical structure: The aversiveness of vanillin, vanillyl alcohol, and veratryl alcohol
Abstract The effectiveness of bird repellents is associated with the presence of an electron-withdrawing group (carbonyl or carboxyl) and an electron-donating group in resonance on a phenyl ring. The
Behavioral and physiological effects of capsaicin in red-winged blackbirds
To the authors' knowledge, the present work is the first to report physiological and behavioral effects of capsaicin on birds, and theFirst to suggest that the substance may have different behavioral and physiological effects on different classes of animals.
Nociception in pigeons is not impaired by capsaicin
The demonstrated insensitivity of pigeons to the algesic effect of capsaicin is discussed in the context of the inability of the drug to deplete substance P (SP) from afferent terminals in the spinal cord of the pigeon.
Anthranilate repellency to starlings: chemical correlates and sensory perception
Physicochemical parameters that control volatility were positively correlated with avoidance and Nasal trigeminal chemoreception and olfaction were important for sensory detection in anthranilate repellency.
Ortho-aminoacetophenone repellency to birds : similarities to methyl anthranilate
OAP has an odor similar to that of methyl anthranilate and is chemically (structurally) similar to Ortho-aminoacetophenone, and was repellent at concentrations ≤0.01% in both choice and no-choice feeding tests.
Olfactory Discrimination of Plant Volatiles by the European Starling
This investigation focused on the chemosensory ability of birds because chemical cues are more directly related to the desired effect of fumigation, whereas visual cues, such as leaf shape, size, and color correlates less well with biocidal properties of plants.
Interactions of various agrochemicals with cytochrome P-450-dependent monooxygenases of wheat cells
Abstract Levels of cytochrome P-450s and rates of monooxygenase activities were studied in microsomes prepared from wheat cell suspension cultures. Cytochrome contents and enzymatic activities,
Trigeminally mediated odor aversions in starlings
It is reported that starlings will learn aversions to odorant volatiles in a feeding context and that these aversions can be mediated by trigeminal cues.
Studies On the Somatotopy of the Trigeminal System in the Mallard, Anas Platyrhynchos L.: I. the Ganglion Trigeminale
In these experiments the labeling of cells was found after much longer survival times than reported generally in the literature, and this long time may depend on a latency period before the damaged axon can take up HRP, as well as on a low rate of transport in the peripheral trigeminal system of the mallard.