Taxol production and taxadiene synthase activity in Taxus canadensis cell suspension cultures.

@article{Hezari1997TaxolPA,
  title={Taxol production and taxadiene synthase activity in Taxus canadensis cell suspension cultures.},
  author={Mehri Hezari and Raymond E. B. Ketchum and Donna M. Gibson and Rodney B. Croteau},
  journal={Archives of biochemistry and biophysics},
  year={1997},
  volume={337 2},
  pages={185-90}
}
The cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene represents the first committed, and a slow, step in the complex biosynthetic pathway leading to the anticancer drug Taxol. The cyclization enzyme, taxadiene synthase, has been previously purified from Pacific yew (Taxus brevifolia) stem and characterized, and the corresponding cDNA has been isolated. To better assess the role of taxadiene synthase in the control of pathway flux in Canadian yew (T. canadensis) cells, a… CONTINUE READING

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