Taxol produces a predominantly sensory neuropathy.

  title={Taxol produces a predominantly sensory neuropathy.},
  author={Richard B. Lipton and Stuart C. Apfel and Janice P Dutcher and Roger Rosenberg and Jocelyn Kaplan and A W Berger and Avi I. Einzig and Peter H. Wiernik and Herbert H. Schaumburg},
  volume={39 3},
Taxol, a plant alkaloid with promise as an antineoplastic agent, produced a predominantly sensory neuropathy in 16 of 60 patients treated in two phase I trials. This neuropathy occurred only at taxol doses greater than 200 mg/m2. Symptoms typically started 1 to 3 days following treatment, beginning in the hands and feet simultaneously in most patients. Electrophysiologic data suggests both axonal degeneration and demyelination. This previously undefined neurotoxic neuropathy most likely results… CONTINUE READING

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