Taxol induces caspase-10-dependent apoptosis.

@article{Park2004TaxolIC,
  title={Taxol induces caspase-10-dependent apoptosis.},
  author={soo-jung Park and C Wu and John D. Gordon and Xiaoling Zhong and Armaghan Emami and Ahmad R. Safa},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 49},
  pages={
          51057-67
        }
}
Taxol (paclitaxel) is known to inhibit cell growth and trigger significant apoptosis in various cancer cells. Although taxol induces apoptosis of cancer cells, its exact mechanism of action is not yet known. In this study we investigated death receptors, FAS-associated death domain protein (FADD), the activation of caspases-10 and -8 as well as the downstream caspases, and reactive oxygen species (ROS) in taxol-induced apoptosis in the CCRF-HSB-2 human lymphoblastic leukemia cell line… CONTINUE READING

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