Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients

@article{Dougherty2004TaxolinducedSD,
  title={Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients},
  author={Patrick M Dougherty and Juan Pablo Cat{\'a} and Joseph V Cordella and Allen W. Burton and Han-Rong Weng},
  journal={Pain},
  year={2004},
  volume={109},
  pages={132-142}
}
Taxol produces neuropathic pain with three distinct zones of involvement in the extremities. Most distally is an area of on-going pain and proximal to this is a zone of sensory disturbance but not overt pain. These two areas were confined in all but one case to the glabrous skin of the hands and/or feet. More proximal is an area not recognized by the patients as involved with pain or sensory disturbance yet wherein quantitative sensory tests nevertheless reveal altered sensibility. Impairment… CONTINUE READING
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