Taxol increases steady-state levels of lipopolysaccharide-inducible genes and protein-tyrosine phosphorylation in murine macrophages.

Abstract

Taxol, a microtubule stabilizing agent, exhibits promise in the treatment of breast and ovarian tumors. Recently, this novel drug has been shown to activate murine macrophages to express TNF-alpha and to down-regulate TNF-alpha receptors, activities shared by bacterial LPS. Our study sought to determine if taxol could regulate gene expression in murine… (More)

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@article{Manthey1992TaxolIS, title={Taxol increases steady-state levels of lipopolysaccharide-inducible genes and protein-tyrosine phosphorylation in murine macrophages.}, author={Carl L. Manthey and Miriam Brandes and Pramitha Perera and Stefanie N. Vogel}, journal={Journal of immunology}, year={1992}, volume={149 7}, pages={2459-65} }