Taxol differentially modulates the dynamics of microtubules assembled from unfractionated and purified beta-tubulin isotypes.

@article{Derry1997TaxolDM,
  title={Taxol differentially modulates the dynamics of microtubules assembled from unfractionated and purified beta-tubulin isotypes.},
  author={W. Brent Derry and Leslie Wilson and Ikhlas Ahmad Khan and Richard F. Luduena and Mary Ann Jordan},
  journal={Biochemistry},
  year={1997},
  volume={36 12},
  pages={3554-62}
}
Substoichiometric binding of taxol to tubulin in microtubules potently suppresses microtubule dynamics, which appears to be the most sensitive antiproliferative mechanism of taxol. To determine whether the beta-tubulin isotype composition of a microtubule can modulate sensitivity to taxol, we measured the effects of substoichiometric ratios of taxol bound to tubulin in microtubules on the dynamics of microtubules composed of purified alphabeta(II)-, alphabeta(III)-, or alphabeta(IV)-tubulin… CONTINUE READING

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