Taxol and taxotere in bladder cancer: in vitro activity and urine stability

@article{Rangel1994TaxolAT,
  title={Taxol and taxotere in bladder cancer: in vitro activity and urine stability},
  author={Cristina Rangel and Harvey B. Niell and Antonius Miller and Clair E. Cox},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1994},
  volume={33},
  pages={460-464}
}
In this study the antimicrotubular agents taxol, taxotere, and vinblastine were compared for their ability to inhibit the clonal growth of human bladder tumor cell lines using a soft-agar clonogenic assay. The stability of taxol and taxotere was evaluated by high-performance liquid chromatography over a range of pH in human urine. Both taxol and taxotere were shown to maximally inhibit the clonal growth of human bladder cell lines within 1 h of drug incubation. The most active agent in the… CONTINUE READING

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