Taxol and colchicine increase LPS-induced pro-IL-1 beta production, but do not increase IL-1 beta secretion. A role for microtubules in the regulation of IL-1 beta production.

@article{OBrien1995TaxolAC,
  title={Taxol and colchicine increase LPS-induced pro-IL-1 beta production, but do not increase IL-1 beta secretion. A role for microtubules in the regulation of IL-1 beta production.},
  author={James M O'Brien and Mark D Wewers and Steven A. Moore and James N Allen},
  journal={Journal of immunology},
  year={1995},
  volume={154 8},
  pages={4113-22}
}
IL-1 beta is a proinflammatory cytokine secreted chiefly by monocytes and macrophages. Currently, much of its mechanism of processing and secretion is poorly understood, but there is increasing evidence that the microtubule system may be involved. For example, it is known that taxol and colchicine, two drugs that affect microtubule structure and function, increase LPS-induced IL-1 beta release. However, it is not known whether these drugs affect the synthesis of the 31-kDa precursor (pro-IL-1… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…