Taxol and anti-stathmin therapy: a synergistic combination that targets the mitotic spindle.

@article{Iancu2000TaxolAA,
  title={Taxol and anti-stathmin therapy: a synergistic combination that targets the mitotic spindle.},
  author={Cristina Livia Iancu and Sucharita J. Mistry and Steven D. Arkin and George F. Atweh},
  journal={Cancer research},
  year={2000},
  volume={60 13},
  pages={
          3537-41
        }
}
Stathmin is an abundant cytosolic phosphoprotein that plays an important role in the regulation of cellular proliferation. Its major function is to promote depolymerization of the microtubules that make up the mitotic spindle. Taxol is an effective chemotherapeutic agent whose activity is mediated through stabilization of the microtubules of the mitotic spindle. We demonstrate that antisense inhibition of stathmin expression chemosensitizes K562 leukemic cells to the antitumor effects of Taxol… CONTINUE READING

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