Taxol affects nuclear lamina and pore complex organization and inhibits import of karyophilic proteins into the cell nucleus.

@article{Theodoropoulos1999TaxolAN,
  title={Taxol affects nuclear lamina and pore complex organization and inhibits import of karyophilic proteins into the cell nucleus.},
  author={Panayiotis Theodoropoulos and Hara Polioudaki and O Kostaki and S P Derdas and Vassilis Georgoulias and Catherine Dargemont and Spyros D. Georgatos},
  journal={Cancer research},
  year={1999},
  volume={59 18},
  pages={4625-33}
}
Treatment of human carcinoma cells with Taxol induces focal unraveling of the nuclear lamina and extensive clustering or ectopic localization of the nuclear pore complexes. These striking aberrations develop when the cells are transferred to drug-free medium and are allowed to complete mitosis. As could be confirmed by terminal deoxynucleotidyl transferase-mediated nick end labeling assays, 4,6-diamidino-2-phenylindole staining, 5-bromo-2-deoxyuridine incorporation, and examination of the… CONTINUE READING

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