Taxol affects meiotic spindle function in locust spermatocytes

@article{Daub2005TaxolAM,
  title={Taxol affects meiotic spindle function in locust spermatocytes},
  author={Agnes -M. Daub and Manfred Hauser},
  journal={Protoplasma},
  year={2005},
  volume={142},
  pages={147-155}
}
Addition of 0.1 to 10 ΜM taxol to meiotic spindles in locust spermatocytes leads to a concentration dependent promotion of MT assembly at the centrosomes and depletion of MTs at the kinetochores, leading to the formation of prominent asters. In anaphase spindles, the equatorial region of the interzone becomes partly depleted of MTs, too. Microcinematographically, cytostatic effects are highly concentration/time dependent, being most rapid and nearly complete at 10 ΜM taxol, but even in 0.1 ΜM… CONTINUE READING
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