Taxol: mechanisms of action and resistance.

  title={Taxol: mechanisms of action and resistance.},
  author={Susan Band Horwitz and Dalia Cohen and Satish Rao and Israel Ringel and H J Shen and Chuan Ping Yang},
  journal={Journal of the National Cancer Institute. Monographs},
Information on the mechanisms of action and of resistance to Taxol, as well as new data from our laboratory on the promoter regions of the genes that encode P-glycoprotein in a murine Taxol-resistant cell line, is discussed. Taxol induces the formation of stable bundles of microtubules, thereby interfering with the normal function of cellular microtubules. The drug can induce the multidrug-resistance (MDR) phenotype that includes the overproduction of P-glycoprotein, a membrane glycoprotein… CONTINUE READING


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