Taxanes propagate apoptosis via two cell populations with distinctive cytological and molecular traits.

@article{Moos1998TaxanesPA,
  title={Taxanes propagate apoptosis via two cell populations with distinctive cytological and molecular traits.},
  author={Philip J. Moos and Frank A. Fitzpatrick},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1998},
  volume={9 8},
  pages={687-97}
}
Taxol and Taxotere propagate apoptosis in Jurkat T cells via molecular signals that coincide with the appearance of two distinct cell populations. Cell cycle arrest in G2-M phase and activation of cell cycle-dependent kinases begin within 2 h and extend to most cells by 16 h. Phosphorylation of Bcl-2 also begins within 2 h and intensifies from 2-16 h. Cell cycle arrest, activation of mitotic kinases, and phosphorylation of Bcl-2 coincided with the appearance of a population of metastable cells… CONTINUE READING
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