Tax1BP1 interacts with papillomavirus E2 and regulates E2-dependent transcription and stability.

@article{Wang2009Tax1BP1IW,
  title={Tax1BP1 interacts with papillomavirus E2 and regulates E2-dependent transcription and stability.},
  author={Xiaoyu Wang and Samisubbu R Naidu and Francis M Sverdrup and Elliot J Androphy},
  journal={Journal of virology},
  year={2009},
  volume={83 5},
  pages={
          2274-84
        }
}
The papillomavirus E2 proteins regulate viral replication, gene transcription, and genome maintenance by interacting with other viral and host proteins. From a yeast two-hybrid screen, we identified the cellular protein Tax1BP1 as a novel binding partner of human papillomavirus type 18 (HPV18) E2. Tax1BP1 also interacts with the HPV16 and bovine papillomavirus type 1 (BPV1) E2 proteins, with the C-terminal region of Tax1BP1 interacting with the N-terminal transactivation domain of BPV1 E2… CONTINUE READING

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