Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression

@inproceedings{Mhleisen2014TaxCA,
  title={Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression},
  author={Annette M{\"u}hleisen and Marco Giaisi and Ronald Koehler and Peter Heinrich Krammer and Min Li-Weber},
  booktitle={Cell Death and Disease},
  year={2014}
}
The human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL). HTLV-1 Tax has been shown to have a prosurvival role in infected T cells by enhancing expression of the Bcl-2 family of antiapoptotic proteins. In this study, we show that the expression of proapoptotic BH3-only proteins Bim (Bcl-2-interacting mediator of cell death) and Bid (BH3-interacting domain death agonist) is diminished in HTLV-1-infected leukemic cells. Using a Tax-inducible system… CONTINUE READING
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