Tautomycin: An inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach

@article{Suganuma2005TautomycinAI,
  title={Tautomycin: An inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach},
  author={M. Suganuma and S. Okabe and E. Sueoka and R. Nishiwaki and A. Komori and N. Uda and K. Isono and H. Fujiki},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2005},
  volume={121},
  pages={621-627}
}
Tautomycin isolated fromStreptomyces spiroverticillatus is an inhibitor of protein phosphatases 1 and 2A. Tautomycin induced hyperphosphorylation of cytokeratin peptides in human keratinocytes (PHK 16-I cells) 30 times less strongly than did okadaic acid. Repeated applications of tautomycin (30 μg, 40 nmol/application) did not induce tumor promotion in a two-stage carcinogenesis experiment on mouse skin initiated with 7,12-dimethylbenz[a]anthracene, whereas okadaic acid (1 μg, 1.2 nmol… Expand
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