Tauroursodeoxycholic acid reduces damaging effects of taurodeoxycholic acid on fundus gastric mucosa.

@article{Piepoli2002TauroursodeoxycholicAR,
  title={Tauroursodeoxycholic acid reduces damaging effects of taurodeoxycholic acid on fundus gastric mucosa.},
  author={Ada Piepoli and R. Caroppo and Raffaele Armentano and Maria Lucia Caruso and Victoria Guerra and Maria Antonietta Maselli},
  journal={Archives of physiology and biochemistry},
  year={2002},
  volume={110 3},
  pages={
          197-202
        }
}
We investigated the effects of tauroursodeoxycholic acid (TUDCA) to assess whether this acid may also have "protective" effects similar to those found with ursodeoxycholic acid (UDCA). We used a well-known amphibian model of gastric mucosa, and studied the effects of taurodeoxycholic acid (TDCA) on electrical transepithelial parameters, acid secretion and histology in absence or in presence of TUDCA. Mucosal exposure to TDCA, after stimulation with histamine, caused a reduction in… CONTINUE READING