Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione.

@article{Colell2001TauroursodeoxycholicAP,
  title={Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione.},
  author={Anna Colell and Olga de Coll and Carmen Garcia-Ruiz and Raquel Par{\'i}s and Claudio Tiribelli and Neil Kaplowitz and Jos{\'e} C Fern{\'a}ndez-Checa},
  journal={Hepatology},
  year={2001},
  volume={34 5},
  pages={964-71}
}
Mitochondrial glutathione (GSH) plays a key role against tumor necrosis factor alpha (TNF)-induced apoptosis because its depletion is known to sensitize hepatocytes to TNF. The present study examined the role of tauroursodeoxycholic acid (TUDCA) administration to chronic ethanol-fed rats on mitochondrial GSH levels and kinetics, mitochondrial membrane physical properties, TNF-induced peroxide formation, and subsequent hepatocyte survival. TUDCA selectively increased the levels of GSH in… CONTINUE READING
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