Tauroursodeoxycholic acid attenuates lipid accumulation in endoplasmic reticulum-stressed macrophages.

@article{Hua2010TauroursodeoxycholicAA,
  title={Tauroursodeoxycholic acid attenuates lipid accumulation in endoplasmic reticulum-stressed macrophages.},
  author={Yinan Hua and Machender Reddy Kandadi and Meijun Zhu and Jun Ren and Nair Sreejayan},
  journal={Journal of cardiovascular pharmacology},
  year={2010},
  volume={55 1},
  pages={49-55}
}
BACKGROUND/AIM Recent evidence suggests that endoplasmic reticulum (ER) stress provoked under diabetic conditions augments the expression of scavenger receptors on macrophages, promoting the uptake of oxidized low-density lipoprotein uptake and atherogenesis. The aim of the present study was to test the hypothesis that the chemical chaperone tauroursodeoxycholic acid (TUDCA) attenuates lipid accumulation in macrophages subjected to ER stress. METHODS Cultured human macrophages were subjected… CONTINUE READING