Tauroursodeoxycholic Acid Prevents MPTP-Induced Dopaminergic Cell Death in a Mouse Model of Parkinson’s Disease

@article{CastroCaldas2012TauroursodeoxycholicAP,
  title={Tauroursodeoxycholic Acid Prevents MPTP-Induced Dopaminergic Cell Death in a Mouse Model of Parkinson’s Disease},
  author={Margarida Castro-Caldas and Andreia Neves Carvalho and Elsa Rodrigues and Colin J. Henderson and C. R. Wolf and Cec{\'i}lia Maria Pereira Rodrigues and Maria Jo{\~a}o Gama},
  journal={Molecular Neurobiology},
  year={2012},
  volume={46},
  pages={475-486}
}
Mitochondrial dysfunction and oxidative stress are implicated in the neurodegenerative process in Parkinson’s disease (PD). Moreover, c-Jun N-terminal kinase (JNK) plays an important role in dopaminergic neuronal death in substantia nigra pars compacta. Tauroursodeoxycholic acid (TUDCA) acts as a mitochondrial stabilizer and anti-apoptotic agent in several models of neurodegenerative diseases. Here, we investigated the role of TUDCA in preventing 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine… CONTINUE READING

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Animal models of Parkinson's disease.

Parkinsonism & related disorders • 2012
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