Taurolithocholate-induced intrahepatic cholestasis: potentiation by methyl isobutyl ketone and methyl n-butyl ketone in rats.

@article{Plaa1985TaurolithocholateinducedIC,
  title={Taurolithocholate-induced intrahepatic cholestasis: potentiation by methyl isobutyl ketone and methyl n-butyl ketone in rats.},
  author={G. Plaa and P. Ayotte},
  journal={Toxicology and applied pharmacology},
  year={1985},
  volume={80 2},
  pages={
          228-34
        }
}
  • G. Plaa, P. Ayotte
  • Published 1985
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
Haloalkane-induced hepatonecrogenesis can be potentiated by the prior administration of methyl isobutyl ketone (MIBK) and methyl n-butyl ketone (MBK). We investigated the possibility that these ketones could potentiate the cholestasis induced by taurolithocholate (TLC) in rats. Daily ketone pretreatment for 3 or 7 days resulted in an enhancement of the diminution in bile flow observed after TLC challenge. When the ketones were administered without TLC challenge, cholestasis was not observed; in… Expand
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