Taurolidine induces epithelial-mesenchymal transition via up-regulation of the transcription factor Snail in human pancreatic cancer cell lines

@article{Hotz2014TaurolidineIE,
  title={Taurolidine induces epithelial-mesenchymal transition via up-regulation of the transcription factor Snail in human pancreatic cancer cell lines},
  author={B. Kaser Hotz and Ulrike Erben and Marco Arndt and Heinz Johannes Buhr and Hubert G. Hotz},
  journal={International Journal of Colorectal Disease},
  year={2014},
  volume={29},
  pages={1339-1348}
}
PurposeThe taurine derivative taurolidine (TRD) exerts anti-neoplastic effects in a variety of tumor models. On the other hand, TRD at low doses was shown to reduce cell-cell adhesion, a prerequisite for metastasis. The aim of this study was to elucidate the effects of low-dose TRD on pancreatic cancer.MethodsHuman pancreatic cancer cell lines representing diverse states of differentiation were exposed to TRD for 24 h. Cell viability was assessed by MTT assay and trypan blue staining, apoptosis… CONTINUE READING
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