Taurolidine and Catheter-related Bloodstream Infection: A Systematic Review of the Literature

  title={Taurolidine and Catheter-related Bloodstream Infection: A Systematic Review of the Literature},
  author={Joanne H Bradshaw and John W. L. Puntis},
  journal={Journal of Pediatric Gastroenterology and Nutrition},
Background: Catheter-related bloodstream infection remains the most common serious complication associated with long-term parenteral nutrition. Taurolock (Bio-Implant HealthCare, Winsen, Germany), which contains taurolidine, is being marketed as a central venous catheter lock solution for decreasing the risk of catheter sepsis. Aim: To review available literature and examine the evidence for efficacy of taurolidine in prevention of central venous catheter–related infection. Materials and… 

Preventing Catheter-Related Bacteremia with Taurolidine-Citrate Catheter Locks: A Systematic Review and Meta-Analysis

Catheter locking with TCLS reduced the risk of CRB and Gram-negative bacterial infection and raised the likelihood of adverse events including thrombotic events.

Taurolidine Lock Solutions for the Prevention of Catheter-Related Bloodstream Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The use of TLS reduced the incidence of CRBSIs without obvious adverse effects or bacterial resistance, however, the susceptibility of G+ and G- bacteria to taurolidine and the risk for catheter-associated thrombosis of TLS are indeterminate due to limited data.

Meta‐analysis of the efficacy of taurolidine in reducing catheter‐related bloodstream infections for patients receiving parenteral nutrition

Taurolidine provides effective CRBSI reduction for people with intestinal failure receiving parenteral nutrition, and showed superior efficacy over controls regardless of study design or comparator group.

Efficacy of Taurolidine on the Prevention of Catheter-related Bloodstream Infections in Patients on Home Parenteral Nutrition

Taurolidine is no substitute for careful aseptic technique, however, it is clearly effective at preventing CRBSIs and should be used in patients with recurrent infections to reduce morbidity.

Catheter-Related Infection (CRI) Treatment with Taurolidine - Citrate Lock Solution in Patients Undergoing Total Parenteral Nutrition

The efficacy of TC in this series of case reports has made possible to resolve all CRI with simple outpatient treatments and therefore could be a further task in the management of infective TPN complication.

Is Taurolidine-citrate an effective and cost-effective hemodialysis catheter lock solution? A systematic review and cost- effectiveness analysis

The results of this analysis indicated that taurolidine-citrate, compared to heparin, was more effective in preventing catheter-related infection; therefore, it could be considered as a superior strategy.

Taurolidine Lock Is Superior to Heparin Lock in the Prevention of Catheter Related Bloodstream Infections and Occlusions

Comparisons with previous studies suggest that catheter locking with taurolidine decreases catheter-related bloodstream infections and occlusions in HPN patients compared with heparin.

Significant Reduction in Central Venous Catheter–related Bloodstream Infections in Children on HPN After Starting Treatment With Taurolidine Line Lock

Taurolidine line lock was associated with a decreased incidence of catheter-related bloodstream infections, and this finding supports its use in patients with a history of septicemia on treatment with cyclical PN.

Taurolidine-citrate-heparin lock reduces catheter-related bloodstream infections in intestinal failure patients dependent on home parenteral support: a randomized, placebo-controlled trial.

In patients with intestinal failure who are life dependent on HPS, the taurolidine-citrate-heparin catheter lock demonstrates a clinically substantial and cost-beneficial reduction of CRBSI occurrence in a high-risk population compared with heparin.



Taurolidine is effective in the treatment of central venous catheter-related bloodstream infections in cancer patients.

Taurolidine 2% as an antimicrobial lock solution for prevention of recurrent catheter-related bloodstream infections.

Data support previous observations made outside North America and suggest that taurolidine may prove to be an effective and safe antimicrobial agent for the prevention of recurrent catheter-related bloodstream infections.

Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution.

  • M. BetjesM. van Agteren
  • Medicine, Biology
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2004
Catheter filling with a solution containing the antimicrobial taurolidine appears to be effective and safe and does not carry the risk for side effects that have been reported for other antimicrobial lock solutions containing gentamicin or high concentrations of citrate.

[Catheter lock solution--taurolock for prevention of catheter-related bacteremia in hemodialysis patients].

The catheter lock solution TauroLock significantly decreased the rate of CRB in HD patients with TCC, to complete prevention in new TCC.

Stability and in vitro efficacy of antibiotic-heparin lock solutions potentially useful for treatment of central venous catheter-related sepsis.

These solutions now warrant clinical trials to investigate their role in the management of catheter-related septicaemia and are identified as promising antibiotic-anticoagulant solutions.

Antimicrobial Activity of a Novel Catheter Lock Solution

It is suggested that taurolidine-citrate is a promising combination agent for the prevention and treatment of intravascular catheter-related infections.

Two Years’ Experience with Dialock® and CLSTM (A New Antimicrobial Lock Solution)

Results of a German Dialock®/CLS study are reported, the first study using an antimicrobial catheter locking solution in a large number of patients, to demonstrate the safety and efficacy of the Dialock in combination with a new heparin-free antimicrobial lock solution.

Prophylaxis against dialysis catheter-related bacteremia with a novel antimicrobial lock solution.

  • M. Allon
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2003
Catheter lock solution dramatically reduces the frequency of catheter-related bacteremia among patients undergoing hemodialysis, although there is an increased requirement for thrombolytic interventions to maintain catheter patency.