Taurolidine–a new drug with anti-tumor and anti-angiogenic effects

  title={Taurolidine–a new drug with anti-tumor and anti-angiogenic effects},
  author={Christoph Andreas Jacobi and Charalambos Menenakos and Chris Braumann},
  journal={Anti-Cancer Drugs},
Taurolidine [bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methane (TRD)], a product derived from the aminosulfoacid taurin, was first described as an anti-bacterial substance. It was mainly used in the treatment of patients with peritonis as well as antiendoxic agent in patients with systematic inflammatory response syndrome. Meanwhile, quite interesting new experimental findings elucidated several new mechanisms concerning not only antibiotic but also anti-tumor effects. TRD significantly… 

Taurolidine: a novel anti-neoplastic agent induces apoptosis of osteosarcoma cell lines

Data indicate that taurolidine possesses potent anti-neoplastic activity against osteosarcoma cell lines and may have potential as a novel OS chemotherapeutic agent.

Redox-directed cancer therapeutics: Taurolidine and Piperlongumine as broadly effective antineoplastic agents (Review)

Taurolidine is particularly advantageous in surgical oncology as this taurine-derivative can be applied perioperatively or systemically with good tolerability as shown in initial clinical applications.

Dual functionality of the antimicrobial agent taurolidine which demonstrates effective anti-tumor properties in pediatric neuroblastoma

In vivo experiments in xenograft mouse models show that taurolidine decreases tumor growth and improves survival, and support the rationale for further evaluation of t Taurolidine for the treatment of relapsed/refractory neuroblastoma patients in an early phase clinical trial.

Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer.

Results indicated that TRD may contribute to cell apoptosis by inducing GRIM‑19 expression and deactivating the STAT3 signaling pathway in liver cancer cells.

Is Taurolidine a candidate for treatment of rheumatoid arthritis?

Results from AIA and from in vitro RA FLS studies suggest that intra-articular administration of TRD could be used as a "pharmacological scalpel" to remove the inflamed synovium.

Evaluation of the Cytotoxic Effects of the Novel Antineoplastic Agent 1,4,5-Oxathiazinane-4,4-dioxide on Triple Negative Breast Cancer Cells

OTD is strongly cytotoxic to both primary and metastatic TNBC cells, possibly by inducing multiple cell death pathways by inducing a reactive oxygen species-dependent mechanism.

Taurolidine and oxidative stress: a rationale for local treatment of mesothelioma

A promising molecular rationale for TN as local treatment of malignant mesothelioma is provided, driven by oxidative stress and cell exposure to sulfydryl donors, such as glutathione monoethylester and l-N-acetylcysteine, which significantly reduced pro-apoptotic effects and Akt inhibition.

Synergistischer Effekt von Taurolidin und rhTRAIL bei der Apoptose-Induktion in HCT15 Coloncarcinom Zellen

A synergistic effect of human recombinant TRAIL and Taurolidin on apoptosis induction of human colon carcinoma cells in vitro is shown for the first time, clearly exceeding a simply additive effect.

Single Versus Double Ring Structure: Search for Best Anti-Neoplastic Driver in Colon and Pancreatic Cancer Cells-Taurultam or Taurolidine?

TAU revealed a significant cytotoxic and anti-proliferative effect on all pancreatic and colon cancer cell-lines as well in MTT- and BrdU- assays as in the real-time cell analyzer, suggesting that the efficiency of TRD against cancer cells is rather based on the methylol-containing species released during hydrolysis.

Comparative analysis of cell death induction by Taurolidine in different malignant human cancer cell lines

The first study providing a simultaneous evaluation of the anti-neoplastic action of TRD across several malignant cell lines indicates, that TRD is likely to provide multifaceted cell death mechanisms leading to a cell line specific diversity.

Taurolidine: cytotoxic and mechanistic evaluation of a novel antineoplastic agent.

Assessment of the antiproliferative activity of this agent in selected human and murine tumor cell lines found it inhibited both tumor formation and growth and increased the appearance of DNA debris in the sub-G(0)/G(1) region, an effect consistent with an induction of apoptosis.

Mechanistic and antineoplastic evaluation of taurolidine in the DU145 model of human prostate cancer

Taurolidine induced mitochondrial-mediated apoptosis in DU145 human prostate tumor cells and this effect could be exploited for therapeutic advantage.

The tumor‐suppressive reagent taurolidine is an inhibitor of protein biosynthesis

It is shown that taurolidine treatment reduces endogenous levels of IκBα, p105, c‐Jun, p53 and p27 in a dose‐dependent manner in colon adenocarcinoma cells, which can be in part due to massive cell death.

The Effects of Taurolidine, a Novel Antineoplastic Agent, on Human Malignant Mesothelioma

Taurolidine has significant antineoplastic activity against MM in vitro and in vivo, in part, due to tumor cell apoptosis, and warrant further study for potential clinical usefulness.

Taurolidine Inhibits Tumor Cell Growth In Vitro and In Vivo

Taurolidine inhibits the growth of a rat metastatic colorectal tumor cell line in vitro and in vivo and thus may have potential in the prevention of peritoneal metastases.

Taurolidine, an antilipopolysaccharide agent, has immunoregulatory properties that are mediated by the amino acid taurine

In addition to its bactericidal and antilipopolysaccharide activity, taurolidine primes PMØs for enhanced antimicrobial activity and these effects appear mediated by the amino acid taurine.

The antibacterial drug taurolidine induces apoptosis by a mitochondrial cytochrome c-dependent mechanism.

Data is presented to show that TRD, at concentrations below the doses that are used to treat patients in the clinic, induces apoptosis of human leukemia HL-60 cells by a mitochondrial cytochrome c-dependent pathway.

[In vitro effect of taurolidine on squamous cell carcinoma in the oral cavity].

The findings showed a significant inhibition of cell proliferation and induction of apoptosis in taurolidine-treated cells SCC 4 and SCC 15 in contrast to the reference group treated with povidone iodine or the untreated control group.

Enhancement of Fas-ligand-mediated programmed cell death by taurolidine.

The antineoplastic activity of taurolidine seems to be partially based on the enhancement of Fas-ligand-induced apoptosis, and t Taurolidine was demonstrated to have an antieoplastic effect independent of Fas -ligand.