Taurodeoxycholate activates potassium and chloride conductances via an IP3-mediated release of calcium from intracellular stores in a colonic cell line (T84)

@article{Devor1993TaurodeoxycholateAP,
  title={Taurodeoxycholate activates potassium and chloride conductances via an IP3-mediated release of calcium from intracellular stores in a colonic cell line (T84)},
  author={Daniel C Devor and M. Chandra Sekar and Raymond A Frizzell and Michael E. Duffey},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 5},
  pages={2173-81}
}
Whole-cell patch-clamp techniques and fluorescence measurements of intracellular Ca2+ concentration, (Ca2+)i, were used to investigate the mechanism of taurodeoxycholate (TDC) stimulation of Cl- secretion in the T84 colonic cell line. During perforated whole-cell recordings, the cell membrane voltage was alternately clamped to EK and ECl. Initially, TDC (0.75 mM) stimulated inward nonselective cation currents that were composed of discrete large conductance single-channel events. This initial… CONTINUE READING

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