Taurine suppresses the spread of cell death in electrically coupled RPE cells

@article{Udawatte2008TaurineST,
  title={Taurine suppresses the spread of cell death in electrically coupled RPE cells},
  author={Chandani Udawatte and Haohua Qian and Nancy J. Mangini and Brian G. Kennedy and Harris Ripps},
  journal={Molecular Vision},
  year={2008},
  volume={14},
  pages={1940 - 1950}
}
PURPOSE To determine whether taurine exerts a protective effect on retinal pigment epithelium (RPE) cells exposed to a cytotoxic agent, cytochrome C (cyC), shown previously to induce apoptosis and produce cell death in electrically coupled neighboring cells. METHODS Monolayer cultures of confluent human RPE (ARPE-19) cells, which express gap-junctional proteins, were incubated in culture medium with or without taurine. After scrape loading cyC into the cells, we assayed these cells for… CONTINUE READING