Taurine relaxes human radial artery through potassium channel opening action

  title={Taurine relaxes human radial artery through potassium channel opening action},
  author={Kemal Gokhan Ulusoy and Erkan Kaya and Kubilay Karabacak and Melik Seyrek and Ibrahim Duvan and Vedat Yıldırım and Oguzhan Yildiz},
  journal={The Korean Journal of Physiology \& Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology},
  pages={617 - 623}
  • K. G. UlusoyE. Kaya O. Yildiz
  • Published 30 October 2017
  • Biology, Chemistry
  • The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, a precontraction was achieved by adding potassium chloride (KCl, 45 mM) or serotonin (5-hydroxytryptamine, 5-HT, 30 µM) to organ baths. When the precontractions were stable, taurine (20, 40, 80 mM) was added cumulatively. Antagonistic effect of taurine on calcium chloride (10 µM to 10 mM)-induced… 

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