Taurine relaxes human radial artery through potassium channel opening action
@article{Ulusoy2017TaurineRH, title={Taurine relaxes human radial artery through potassium channel opening action}, author={Kemal Gokhan Ulusoy and Erkan Kaya and Kubilay Karabacak and Melik Seyrek and Ibrahim Duvan and Vedat Yıldırım and Oguzhan Yildiz}, journal={The Korean Journal of Physiology \& Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology}, year={2017}, volume={21}, pages={617 - 623} }
The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, a precontraction was achieved by adding potassium chloride (KCl, 45 mM) or serotonin (5-hydroxytryptamine, 5-HT, 30 µM) to organ baths. When the precontractions were stable, taurine (20, 40, 80 mM) was added cumulatively. Antagonistic effect of taurine on calcium chloride (10 µM to 10 mM)-induced…
10 Citations
Propofol-Induced Vasodilation in Human Internal Mammary Artery: Role of Potassium Channels.
- Medicine, BiologyJournal of cardiothoracic and vascular anesthesia
- 2018
It is clearly revealed that propofol relaxes the IMA, and prop ofol-induced vasodilation may be related to large conductance calcium ion-activated potassium ion channel activation.
Effects of taurine on vascular tone
- BiologyAmino Acids
- 2022
This review summarizes the role of taurine in vascular tone and blood pressure modulation based on experimental and human studies to facilitate the development of therapeutic and/or diet-based strategies to reduce the burden of vascular diseases.
Potassium channels in vascular smooth muscle: a pathophysiological and pharmacological perspective
- Biology, MedicineFundamental & clinical pharmacology
- 2019
Modulation of K+ channel activity by molecular approaches and selective drug development may be a novel treatment modality for vascular dysfunction in the future.
The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis
- Medicine, BiologyCurrent Hypertension Reports
- 2018
These preliminary findings suggest that ingestion of taurine at the stated doses and supplementation periods can reduce blood pressure to a clinically relevant magnitude, without any adverse side effects.
Physiological and thermoregulatory effects of oral taurine supplementation on exercise tolerance during forced convective cooling
- MedicineEuropean journal of sport science
- 2020
A 50 mg·kg−1 dose of taurine did not statistically benefit endurance exercise after moderate cold exposure but conferred some potential vascular and metabolic effects.
Taurine Metabolism in Humans
- Biology
- 2018
Plasma level of acetyl-taurine increases after exercise, suggesting that taurine contributes to reduce excess intracellularacetyl-coA content, like L-carnitine, and may have beneficial effects on exercise performance.
Cadmium induces placental glucocorticoid barrier damage by suppressing the cAMP/PKA/Sp1 pathway and the protective role of taurine.
- BiologyToxicology and applied pharmacology
- 2022
Metabolism of vascular smooth muscle cells in vascular diseases.
- Biology, MedicineAmerican journal of physiology. Heart and circulatory physiology
- 2020
This review presents a brief overview of VSMCs metabolism, and how it regulates the progression of several vascular diseases, including atherosclerosis, systemic hypertension, diabetes, pulmonary hypertension, vascular calcification, and aneurysms, and the effect of the risk factors for vascular disease (aging, cigarette smoking and excessive alcohol drinking) on VS MCs metabolism.
Using lectures to identify student misconceptions: a study on the paradoxical effects of hyperkalemia on vascular smooth muscle.
- BiologyAdvances in physiology education
- 2020
Assessment of students' in-class knowledge of membrane potential, conductance, and smooth muscle response indicated that students lacked knowledge of specific potassium conductance in various muscle types, resulting in divergent responses, such as the canonical depolarization in skeletal muscle versus hyperpolarization during hyperkalemia.
References
SHOWING 1-10 OF 28 REFERENCES
Effects of taurine on contractions of human internal mammary artery: a potassium channel opening action.
- Biology, MedicineEuropean review for medical and pharmacological sciences
- 2015
The results suggest that mechanism of vasodilator effect of taurine in IMA may be the activation of large conductance Ca2+-activated K+ channels.
Effects of taurine on contractions of the porcine coronary artery.
- Biology, ChemistryPharmacological reports : PR
- 2009
Vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries.
- Biology, MedicineEuropean journal of pharmacology
- 2008
Testosterone relaxes isolated human radial artery by potassium channel opening action.
- Biology, MedicineJournal of pharmacological sciences
- 2007
It is reported for the first time that supraphysiological concentrations of testosterone induces relaxation in RA, and this response may occur in part via ATP-sensitive K(+) channel opening action.
THE EFFECT OF TAURINE ON HIGH POTASSIUM‐ AND NORADRENALINE‐INDUCED CONTRACTION IN RABBIT EAR ARTERY
- Biology, ChemistryBritish journal of pharmacology
- 1982
1 Intraluminal administration of taurine (40 mm) did not affect the contractile tone of rabbit isolated ear artery. 2 Taurine (10–80 mm) exerted a powerful concentration‐dependent, vasodilator action…
Effects of taurine on rat aorta in vitro
- Biology, MedicineFundamental & clinical pharmacology
- 1991
The physiological role of taurine in the maintenance of vascular tone in normal and pathological situations is discussed and its actions are independent of extracellular calcium.
Effects of Taurine on Aortic Rings Isolated from Fructose-fed Insulin Resistance Sprague–Dawley Rat are Changed
- Biology, ChemistryCardiovascular Drugs and Therapy
- 2008
Taurine enhances contractions in IR aortic rings but relaxes thecontractions in normal rat aortIC ring; the enhancement is endothelium-dependent and the relaxation is endot helium-independent.
Verapamil plus nitroglycerin solution maximally preserves endothelial function of the radial artery: comparison with papaverine solution.
- Medicine, BiologyThe Journal of thoracic and cardiovascular surgery
- 1998
Direct inhibitory effects of taurine on norepinephrine-induced contraction in mesenteric artery of stroke-prone spontaneously hypertensive rats.
- Biology, ChemistryAdvances in experimental medicine and biology
- 1996
Results indicate that the hypotensive effect of taurine is accounted for at least in part its direct action on blood vessels.
Vasodilatory effect of hydroxyethyl methacrylate and triethylene glycol dimethacrylate in rat aorta through calcium antagonistic action.
- Medicine, BiologyJournal of endodontics
- 2011