Taurine protects cisplatin induced cardiotoxicity by modulating inflammatory and endoplasmic reticulum stress responses.

@article{Chowdhury2016TaurinePC,
  title={Taurine protects cisplatin induced cardiotoxicity by modulating inflammatory and endoplasmic reticulum stress responses.},
  author={Sayantani Chowdhury and Krishnendu Sinha and Sharmistha Banerjee and Parames Chandra Sil},
  journal={BioFactors},
  year={2016},
  volume={42 6},
  pages={647-664}
}
Oxidative stress, ER stress, inflammation, and apoptosis results in the pathogenesis of cisplatin-induced cardiotoxicity. The present study was designed to investigate the signaling mechanisms involved in the ameliorating effect of taurine, a conditionally essential amino acid, against cisplatin-mediated cardiac ER stress dependent apoptotic death and inflammation. Mice were simultaneously treated with taurine (150 mg kg-1 body wt, i.p.) and cisplatin (10 mg kg-1 body wt, i.p.) for a week… CONTINUE READING