Taurine inhibits the phosphorylation of two endogenous proteins (M(r) ? 140 and ?20 K) in subcellular preparations of rat cortex.

@article{Li1990TaurineIT,
  title={Taurine inhibits the phosphorylation of two endogenous proteins (M(r) ? 140 and ?20 K) in subcellular preparations of rat cortex.},
  author={Ya Ping Li and John B. Lombardini},
  journal={Neurochemistry international},
  year={1990},
  volume={17 3},
  pages={389-99}
}
The effects of exogenous taurine on the phosphorylation of proteins in hypo-osmotically shocked synaptosomes (P(2) fraction) prepared from rat cortex were investigated. Taurine (2-20 mM) inhibited the phosphorylation of two bands of protein with molecular weights of ? 140 and ? 20 K in a concentration related manner as shown by one-dimensional SDS-PAGE. Kinetic studies using 10 mM tauring demonstrated that the inhibitory effect occurred at approx. 1 min after the start of the reaction… CONTINUE READING