Taurine inhibits rat substantia nigra pars reticulata neurons by activation of GABA- and glycine-linked chloride conductance.

Abstract

Whole-cell recordings from rat midbrain slices showed that bath application of taurine (30 microM-10 mM) reversibly hyperpolarized and inhibited the firing of substantia nigra pars reticulata neurons. These effects were mediated by an increase in membrane chloride conductance. Taurine cross-desensitized with GABA and glycine. Strychnine competitively… (More)

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