Taurine inhibits rat substantia nigra pars reticulata neurons by activation of GABA- and glycine-linked chloride conductance.


Whole-cell recordings from rat midbrain slices showed that bath application of taurine (30 microM-10 mM) reversibly hyperpolarized and inhibited the firing of substantia nigra pars reticulata neurons. These effects were mediated by an increase in membrane chloride conductance. Taurine cross-desensitized with GABA and glycine. Strychnine competitively… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.