Taurine haloamines and heme oxygenase-1 cooperate in the regulation of inflammation and attenuation of oxidative stress.

@article{Marcinkiewicz2009TaurineHA,
  title={Taurine haloamines and heme oxygenase-1 cooperate in the regulation of inflammation and attenuation of oxidative stress.},
  author={Janusz Marcinkiewicz and Maria Walczewska and Rafał Olszanecki and Małgorzata Bobek and Rafał Biedroń and Jozef Dulak and Alicja Jozkowicz and Ewa Kontny and Włodzimierz Maśliński},
  journal={Advances in experimental medicine and biology},
  year={2009},
  volume={643},
  pages={439-50}
}
Taurine chloramine (TauCl) and Taurine bromamine (TauBr), products of the neutrophil myeloperoxidase halide system, exert anti-inflammatory properties. They inhibit the production of a variety of inflammatory mediators, such as prostaglandin E2 (PGE2), nitric oxide (NO) and proinflammatory cytokines. Heme oxygenase-1 (HO-1), a stress inducible enzyme, degrades heme to biliverdin, free iron and carbon monoxide (CO), which are involved in the anti-inflammatory and antioxidant actions of HO-1… CONTINUE READING