Taurine chloramine inhibition of cell proliferation and cytokine production by rheumatoid arthritis fibroblast-like synoviocytes.

@article{Kontny1999TaurineCI,
  title={Taurine chloramine inhibition of cell proliferation and cytokine production by rheumatoid arthritis fibroblast-like synoviocytes.},
  author={Ewa Kontny and Anna I Grabowska and Jacek Kowalczewski and Mariola Kurowska and Iwona Janicka and Janusz Marcinkiewicz and Wlodzimierz Maśliński},
  journal={Arthritis and rheumatism},
  year={1999},
  volume={42 12},
  pages={2552-60}
}
OBJECTIVE To examine whether taurine (Tau) or its physiologic chlorinated derivative, taurine chloramine (Tau-CI), affects proliferation of, and proinflammatory cytokine (interleukin-6 [IL-6] and IL-8) production by, fibroblast-like synoviocytes (FLS) isolated from rheumatoid arthritis (RA) patients. METHODS FLS, isolated from the synovial tissue of 19 RA patients and cultured in vitro for 3-6 passages, were stimulated with the recombinant human cytokines IL-1beta (1 ng/ml), tumor necrosis… CONTINUE READING

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