Taurine chloramine, an oxidant derived from neutrophils, induces apoptosis in human B lymphoma cells through mitochondrial damage.

@article{Klamt2005TaurineCA,
  title={Taurine chloramine, an oxidant derived from neutrophils, induces apoptosis in human B lymphoma cells through mitochondrial damage.},
  author={F{\'a}bio Klamt and Emily Shacter},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 22},
  pages={
          21346-52
        }
}
Taurine chloramine (TN-Cl) is one of the most abundant compounds generated by activated neutrophils. In contrast to HOCl, which causes necrosis, TN-Cl is a potent inducer of apoptosis in tumor cells. Here we show that the apoptosis induced by TN-Cl in human B lymphoma cells is dependent upon oxidant-mediated mitochondrial damage, a decrease in mitochondrial membrane potential, and caspase-9 activation. Further, we show that TN-Cl is taken up into the cells and is concentrated in the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 37 CITATIONS

Taurine chloramine induces apoptosis in human osteosarcoma cell lines.

  • Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • 2012
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Role of the Vanins–Myeloperoxidase Axis in Colorectal Carcinogenesis

  • International journal of molecular sciences
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

Anti-Inflammatory Effect of Taurine in Burned Patients.

  • Advanced pharmaceutical bulletin
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND